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More info
You can access this
clinical trial
if you have
Axial and Peripheral Spondyloarthritis or Rheumatoid Arthritis
and you are
between 18 and 70
years old
3
This is a trial in the final phase before the treatment is released on the market.
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The purpose

In this open-label monocentric explorative pilot trial the objective is to show the biodistribution of TNFα by administration of radiolabeled anti-TNFα in patients with active rheumatoid arthritis and spondylarthropathy. The anti-TNFα used in this trial is certolizumab pegol (Cimzia®), a pegylated Fab'-fragment of a monoclonal antibody with high specificity for TNFα. Certolizumab pegol will be radiolabeled with 99mTechnetium. The aim of this study is to show the TNFα triggered inflammation process in the inflamed joints, especially in patients who have very early joint damage where currently other imaging methods such as X-rays are not sensitive enough for detection.

Provided treatments

  • Drug: administration of Cimzia®
  • Drug: Immunoscintigraphy with radiolabeled Cimzia®.

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01590966. The sponsor of the trial is University Hospital, Ghent and it is looking for 41 volunteers for the current phase.
Official trial title:
Scintigraphic Detection of the Biodistribution of Tumor Necrosis Factor With a Radiolabeled Anti-TNFα in Patients With Active Rheumatoid Arthritis and Active Axial and Peripheral Spondyloarthritis