Utilizing fMRI, this study will examine changes in BOLD signal as a proxy measure of brain
activation in response to highly palatable (high energy density [kcal/g]), less palatable and
non-food stimuli in severely obese women pre, 1 month post and 3 months post undergoing
bariatric surgery (in surgery patients) and at equivalent times for control groups in fed and
fasted conditions at each time point.
Two surgical groups: (i) laparoscopic Roux-en-Y gastric bypass (RYGB) and (ii) gastric
banding (GB) will be compared with two control groups: (i)those enrolled on a 3-month formula
weight loss program or (ii) those who qualify, but do not undergo bariatric surgery, and
receive no weight loss treatment.