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Your journey
1What's a trial
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More info
You can access this
clinical trial
if you have
Dental Caries or Dental Fluorosis
and you are
between 3 and 4
years old
This is an early phase trial to determine
the dosage and safety of the new treatment.
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The purpose

Fluoride toothpaste has been associated not only with declining dental caries prevalence but also with an increase in dental fluorosis. In the balance of benefits/risks of fluoride toothpaste use, the purpose of this study is to evaluate the availability of fluoride concentration in the mouth (biofilm fuild), as an indicator of fluoride benefits (anticaries effect), and the fluoride concentration in urine, as an indicator of fluoride absorption from ingested toothpastes (with potential to cause dental fluorosis), in a sample of young Brazilian children using toothpaste formulations representative of those available and most used by this age-group.

Provided treatments

  • Drug: Toothpaste

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01589991. The sponsor of the trial is University of Campinas, Brazil and it is looking for 24 volunteers for the current phase.
Official trial title:
Anticaries Potential and Fluorosis Risk From Different Fluoride Toothpastes