The purpose of the interventional study is to determine whether Nicotinamide is effective at
upregulating the Frataxin (FXN) gene in patients with Friedreich's ataxia (FRDA) where this
gene is abnormally 'switched off'.
The purpose of the non-interventional study is to investigate the use of novel,
highly-sensitive technology to capture clinical deficit and measure subtle changes in the
activities of daily living and to correlate functional changes to levels of expression of
Frataxin protein and the epigenetic structure of the Frataxin gene over a 9-12 month period
without nicotinamide. Healthy volunteers will be included as comparators in this part of the