The main aims of this study are:
- to investigate and compare the effects of long lasting use (59 weeks) of vaginal and
oral contraceptives on androgen secretion, insulin and glucose metabolism, lipid
profile, and serum levels of SHBG and hs-CRP in women with PCOS.
- to compare the metabolic effects of oral and vaginal combined contraceptives and to find
out whether oral or transvaginal contraceptive can be recommended to a particular group
of women, for example in women with increased metabolic risks.
- to clarify whether the unfavourable effects of combined contraceptives diminish with
time (after use of one year).