The DERENEDIAB study is a proof-of-concept, multi-center, prospective, open, randomized,
controlled study of the effectiveness of renal denervation in addition to standardized
medical treatment compared to medical treatment alone in diabetic subjects with diabetic
nephropathy and resistant proteinuria. Bilateral renal denervation will be performed using
the Symplicity Catheter - a percutaneous system that delivers radiofrequency (RF) energy
through the luminal surface of the renal artery.