Hormonal disturbances in the GH-IGF-I axis are considered important for the deterioration of
glycemic control in T1DM particularly in adolescents. In addition it may have direct
implications on the development of insulin resistance and long-term complications.
The Investigators hypothesis is that low circulating IGF-I and compensatory hyper-secretion
of GH, in the presence of peripheral insulin excess, results in increased local IGF-I
expression explaining both the deterioration in metabolic control and the increased risk for
microvascular complications. Correction of imbalance in circulating and tissue-specific
levels of IGF-I could lead to both better early metabolic control and to prevention of early
diabetic complications in type 1 diabetic (T1DM) patients.
Aim of the present study is to validate the microdialysis technique as a useable tool to
predict local biological effects of IGF-1 and to understand the pharmacokinetics of local
IGF-I actions after sc injection of Increlex in type 1 diabetic patients.