The proposed project will use fMRI and specific probes of reward and inhibition as biomarkers
predicting drug use during and after treatment in 72 subjects addicted to prescription
opioids/medications. Subjects will be scanned before, during, and after 12 weeks of active
medication. The brain fMRI measures will be correlated with the primary clinical outcome of
drug use (by urine drug screen) during the treatment and follow-up phase.