Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults. The treatment
comprises maximal safe resection followed by radiotherapy and chemotherapy. Despite
appropriate management, 90% of the patients will develop relapse or progression. After
progression, the median survival is 5.2 months (Stupp, 2009).
The treatment of GBM relapse remains investigational. Reirradiation is an option in selected
The objective of this study is to compare 2 schemes of stereotactic hypofractionated
radiotherapy in the management of recurrent GBM.