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More info
You can access this
clinical trial
if you have
Pain or Intravenous Propofol Injection
and you are
between 18 and 60
years old
-
The phase for this study is not defined.
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The purpose

Propofol is commonly used IV anesthetic, it has been formulated in a concentration of 10 mg/ml in a fat emulsion consisting of 10% soybean oil (long-chain triglycerides). When used for anesthetic induction, propofol causes pain on injection in 28%-90% of patients. pain probably results from a direct irritant effect. Several methods have been used to reduce this pain. Lidocaine pretreatment has been commonly proposed to decrease propofol induced pain, but its failure rate is between 13-32%. Dexmedetomidine is highly selective alfa-2 adrenoreceptor agonist. Alpha-2 receptors are located on blood vessels where they inhibit norepinephrine release. Investigators, therefore, speculated that dexmedetomidine could attenuate the pain due to injection of propofol. Investigators conducted a study to determine the efficacy of dexmedetomidine in decreasing pain due to injection of propofol.

Provided treatments

  • Drug: I.V injection of 10 ml normal saline
  • Drug: I.V injection with 0.25mic/kg of dexmedetomidine
  • Drug: I.V injection of 0.50mic/kg of dexmedetomidine

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01463332. The sponsor of the trial is KVG Medical College and Hospital and it is looking for 150 volunteers for the current phase.
Official trial title:
Effect of Dexmedetomidine on Pain Due to Propofol Injection:A Randomised, Double-blind, Controlled Clinical Trial