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More info
You can access this
clinical trial
if you have
Pain or Intravenous Propofol Injection
and you are
between 18 and 60
years old
The phase for this study is not defined.
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The purpose

Propofol is commonly used IV anesthetic, it has been formulated in a concentration of 10 mg/ml in a fat emulsion consisting of 10% soybean oil (long-chain triglycerides). When used for anesthetic induction, propofol causes pain on injection in 28%-90% of patients. pain probably results from a direct irritant effect. Several methods have been used to reduce this pain. Lidocaine pretreatment has been commonly proposed to decrease propofol induced pain, but its failure rate is between 13-32%. Dexmedetomidine is highly selective alfa-2 adrenoreceptor agonist. Alpha-2 receptors are located on blood vessels where they inhibit norepinephrine release. Investigators, therefore, speculated that dexmedetomidine could attenuate the pain due to injection of propofol. Investigators conducted a study to determine the efficacy of dexmedetomidine in decreasing pain due to injection of propofol.

Provided treatments

  • Drug: I.V injection of 10 ml normal saline
  • Drug: I.V injection with 0.25mic/kg of dexmedetomidine
  • Drug: I.V injection of 0.50mic/kg of dexmedetomidine

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01463332. The sponsor of the trial is KVG Medical College and Hospital and it is looking for 150 volunteers for the current phase.
Official trial title:
Effect of Dexmedetomidine on Pain Due to Propofol Injection:A Randomised, Double-blind, Controlled Clinical Trial