The aim of the exploratory study is to compare dose related effects of LAS41004 formulations
in a non-occlusive PPT.
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Locations near you
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Full eligibility criteria for NCT01462643
Ages eligible for Study
18 Years to 75 Years
Genders eligible for Study
Accepts Healthy Volunteers
18 to 75 years of age
Caucasian men and women
Suffering from mild to moderate plaque psoriasis of at least 6 months duration that is amenable to local therapy
With at least one stable psoriatic plaque in an area sufficient for product application meeting the following criteria:
located at trunk and/or extremities (plaques located on the head, palms, or sole of feet, intertriginous or genitoanal areas are not suitable)
Where more than one plaque is to be used, plaques that are comparable, with at least "2" in each score for scaling, erythema and induration.
No more than 3 points difference in total score (sum of scores for scaling, erythema and induration)
Negative urine pregnancy test (in female patients of child bearing potential)
In the case of women of childbearing potential, using reliable methods of contraception which result in a low failure rate i.e. less than 1% per year (eg contraceptive implants or injectables, combined oral contraceptives, some intrauterine devices, sexual abstinence or vasectomized partner)
Patients who need systemic treatment for their psoriasis
Severe forms of psoriasis or forms of psoriasis other than chronic plaque psoriasis, including:
Changes in the expression of psoriasis within the last 6 weeks prior screening
Intensive UV light exposure within two weeks before the beginning of the test as well as during the study and four weeks after the end of the study at the test area
Systemic treatment (see table below): Corticosteroids, antibiotics 4 weeks prior to study day 1 and during conduct of study Retinoids Ciclosporin Methotrexate Fumaric acid esters 3 months prior to study day 1 and during conduct of study Anti-inflammatory substances, NSAIDs 2 weeks prior to study day 1 and during conduct of study Biologics 6 months prior to study day 1 and during conduct of study Planned initiation of, or changes to concomitant medication that could affect Psoriasis (e.g. beta blockers, anti-malaria drugs, lithium) 8 weeks before study start and during study
Topical treatment of all other body regions with corticosteroids or immunosuppressants where more than 20 % of the body surface area is treated
Treatment with any non-marketed drug substance within 4 weeks prior to study day 1
Topical treatment of the test area without adequate time for washout
Diseases: Skin infections caused by bacteria, viruses or fungi, including but not limited to tuberculosis, syphilis or varicella zoster infection Parasitic infections Rosacea, perioral dermatitis in test area Moderate or severe illness within the last two weeks before first exposure Other known infectious diseases (e.g. hepatitis or AIDS) Other skin diseases that may confound the evaluation of psoriasis
Known hypersensitivity to any ingredients of the study drugs,
Known calcium metabolism disorders
History of malignancy of any organ system
Severe impairment of liver or kidney function
Pregnancy or lactation
Participation in a clinical trial within the last 30 days prior to the start of this study
All locations for NCT01462643
Schenefeld, Germany, 22869
View full eligibility
Tris trial is registered with FDA with number: NCT01462643. The sponsor of the trial is Almirall, S.A. and it is looking for 22 volunteers for the current phase.
Official trial title: A 22 Day Controlled, Randomized Clinical Study (PPT) Investigating the Anti-psoriatic Efficacy and the Tolerability of an Ointment Containing a Retinoid and a Steroid in Different Concentrations
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