The purpose of this study is to determine if there is a genetic component to phantom limb
pain. DNA will be analyzed for single nucleotide polymorphisms (SNPs) between the control and
phantom limb pain group. Total RNA will also be isolated and profiled to asses the degree to
which our gene(s) of interest are expressed in the presence or absence of phantom limb pain.
Some proteins, such as inflammatory antibodies or the neurotrophin brain-derived neurotrophic
factor (BDNF), will also be assessed for their association(s) with phantom limb pain.