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Your journey
1What's a trial
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More info
You can access this
clinical trial
if you have
Idiopathic Pulmonary Fibrosis, Diffuse Parenchymal Lung Disease or Interstitial Lung Disease
and you are
between 21 and 85
years old
The phase for this study is not defined.
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The purpose

Idiopathic pulmonary fibrosis (IPF) is an illness characterized by progressive decline in lung function and premature death from respiratory failure. Fibrocytes are a novel population of bone marrow-derived circulating progenitor cells that have been shown to traffic to the lungs and contribute to fibrosis in animal models of pulmonary fibrosis, and whose numbers correlate with the degree of fibrosis and with survival in human pulmonary fibrosis. The investigators propose to test the hypothesis that therapy with the mTOR inhibitor, sirolimus, reduces the number of circulating fibrocytes in patients with IPF. The investigators propose to test this hypothesis in short-term pilot trial of sirolimus in patients with IPF to determine its effect on the number and phenotype of circulating fibrocytes.

Provided treatments

  • Drug: sirolimus
  • Other: Placebo

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01462006. The sponsor of the trial is University of Virginia and it is looking for 32 volunteers for the current phase.
Official trial title:
Double-blind Placebo-controlled Pilot Study of Sirolimus in IPF