This trial is terminated!
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Your journey
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More info
You can access this
clinical trial
if you have
Respiratory Distress Syndrome, Adult, Gastrointestinal Hemorrhage, Liver Diseases or Transfusion Related Lung Injury
and you are
between 18 and 75
years old
3
This is a trial in the final phase before the treatment is released on the market.
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The purpose

Transfusion-related acute lung injury (TRALI) is the most common cause of transfusion-related morbidity and mortality in the United States. It is very common and often unrecognized in the critically ill with the greatest incidence occurring in bleeding patients with liver disease. Plasma is the most blood component associated with this deadly complication and therefore patients with liver disease who frequently receive transfused plasma are at increased risk. The optimal plasma transfusion strategy for bleeding patients with liver disease is unknown and the investigators will evaluate this clinical question in a small pilot randomized controlled trial. The invstigators hypothesize that targetting a more restrictive INR Target (2.5) vs. an INR Target (1.8) will result in less hypoxemia, a TRALI surrogate without increasing bleeding complications.

Provided treatments

  • Other: Transfuse plasma to High INR target
  • Other: Transfuse plasma to Low INR target

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01461889. The sponsor of the trial is University of Colorado, Denver and it is looking for 50 volunteers for the current phase.
Official trial title:
Transfusion-related Acute Lung Injury in Patients With Liver Disease