STAGE I of the COMET study was to develop an Electronic Network Informatics Infrastructure
that prospectively enabled access to and the sharing of clinical and research data.
STAGE II: This was a Comparative Effectiveness Trial (CET) evaluating positive airway
pressure (PAP) vs. oral appliance (OA) therapy in improving hypertension and abnormalities in
cardiovascular function in overweight/obese patients with obstructive sleep apnea (OSA). Data
collected during the STAGE II study was incorporated in Part 3 of the STAGE I study.
STAGE III of the COMET study was completion of data analysis and preparation of the
electronic network informatics infrastructure for use beyond the four Clinical Centers to
interested CTSA institutions. We also explored expanding ontologies, and the use of federated