The prevalence of obesity and Type 2 diabetes has increased dramatically worldwide. Research
on Glycemic Index (GI) diets has been largely developed, however the combination with
metformin in humans was not investigated yet. We hypothesized that the low-GI diet in
combination with metformin would elicit greater improvements on glucose metabolism, lipid
profile and body composition on overweight or obese type 1 subjects. This study aims to
evaluate the metabolic effects of the adoption of dietary advice to follow caloric
restriction high/low GI diets, and low-GI diet associated with metformin on glucose
metabolism, lipid profile and body composition on overweight or obese type 1 subjects.