Objectives: The investigators propose a first-ever, prospective trial of asenapine in older
adults with bipolar disorder (BD) to evaluate effects on mood symptoms, tolerability and
functional/general health status. Given the dearth of treatment data on older adults with BD,
findings are likely to be of substantial clinical interest, may inform larger future studies
and will assist in refining bipolar treatment recommendations.
Primary: Asenapine therapy will be associated with reduced bipolar manic and depressive
symptoms in older adults with BD.
Secondary: Asenapine therapy will be associated with improved functional and general health
status, improved global psychopathology, and good tolerability in older adults with BD.