The main objective of the study is to assess the survival in patient with non metastatic
osteosarcoma of the extremities treated with different chemotherapy protocols, according to
the expression of ABCB1/P-glycoprotein
Drug: Mifamurtide arm
Other: 3 drugs arm
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Locations near you
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Full eligibility criteria for NCT01459484
Ages eligible for Study
up to 40 Years
Genders eligible for Study
Accepts Healthy Volunteers
Histology confirmed diagnosis of extremities high grade osteosarcoma
Age ≤ 40 years
Localized disease or presence of skip metastasis
Hepatic, renal and bone marrow normal function
LVEF > 50%
No previous surgery and/ or chemotheraputic osteosarcoma treatments,
No more than 4 weeks interval between histological diagnosis and start of chemotherapy
Informed consent to the study participation obtained.
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