Vascular access in patients carries a significant risk of accidental extravasation of
intravenous (IV) fluids and medications with the potential for tissue injury. This
prospective controlled study assessed the diagnostic utility of using intravenous diluted
sodium bicarbonate to confirm placement of IV catheters in volunteers . Diluted sodium
bicarbonate or 0.9% normal saline, will be injected in a randomized order while end-tidal
carbon dioxide in the exhaled air will be monitored. The investigators hypothesize that the
injected bicarbonate will dissolve into carbon dioxide and water and cause a transient
increase in the measured exhaled CO2.
The effect is unique to bicarbonate and will not appear once normal saline is injected. the
safety of the administration of bicarbonate on the metabolic profile of the volunteers will
be assessed by measurement of venous blood pH and electrolytes.