This trial is terminated!
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More info
You can access this
clinical trial
if you have
Eosinophilic Esophagitis
and you are
between 2 and 17
years old
-
The phase for this study is not defined.
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The purpose

Eosinophilic Esophagitis (EE) is a condition where eosinophils (a cell that fights infection) travel to the esophagus (the tube through which food passes to the stomach). These cells do not belong there and can cause pain, soreness, difficulty swallowing and sometimes vomiting. Ways to treat this condition include medicine, not eating some foods, and drinking a specific formula (like milk) without eating any other foods. Doing these things can help fight off EE but these problems can come back when treatment is stopped. If EE symptoms go on for a long time, it can lead to the esophagus becoming narrow and feeling tight when eating and swallowing and surgery may be needed to widen the narrowed area to relieve the sensation of tightening. Montelukast is a medicine that fights off a type of chemical that can be a magnet for eosinophils. People usually take this medicine to help treat their asthma. It is not approved to treat EE. This medication is taken once a day. The purpose of this study is to see if Montelukast, compared to placebo, will help reduce the number of eosinophils in children with EE and help stop the tightening of the esophagus.

Provided treatments

  • Drug: Montelukast
  • Other: placebo
  • Drug: 5 mg Montelukast

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01458418. The sponsor of the trial is Children's Mercy Hospital Kansas City and it is looking for 4 volunteers for the current phase.
Official trial title:
A Trial of Montelukast for Maintenance Therapy of Eosinophilic Esophagitis in Children