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More info
You can access this
clinical trial
if you have
Obesity
and you are
between 18 and 40
years old
-
The phase for this study is not defined.
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The purpose

The purpose of this study is to determine why obese women have lower hormone levels and less fertility than women of normal body weight. The proposal will examine the reproductive system at the level of the brain and the ovary to define the changes that happen leading to lowered hormone production. Women will be studied throughout a menstrual cycle and given medications that will test how well their pituitary gland can make hormones that stimulate the ovary (luteinizing hormone (LH) and follicle stimulating hormone (FSH)). They will also be given a medication to abolish estrogen production in the body and their response to this medication will be assessed. Finally, the ovary's ability to produce progesterone after ovulation will be examined. --Hypotheses: 1. Obese women have reduced pituitary sensitivity to exogenous gonadotropin-releasing hormone (GnRH), but normal clearance of exogenous LH. (comparative study of obese compared to normal weight women) 2. Obese women have abnormally increased sensitivity to estradiol negative feedback which will be reversed by an aromatase inhibitor. (comparative study of obese compared to normal weight women)

Provided treatments

  • Drug: Cetrorelix
  • Drug: Gonadorelin-GnRH
  • Drug: Recombinant LH
  • Drug: Letrozole

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01457703. The sponsor of the trial is University of Colorado, Denver and it is looking for 62 volunteers for the current phase.
Official trial title:
Reproductive Hormonal Alterations in Obesity, AIMS #1 & #2