This is a randomized and single blinded study aimed to compare the efficacy between
intramuscular autologous bone marrow mononuclear cells plus mesenchymal stem cell
implantation and intramuscular autologous bone marrow mononuclear cells implantation only in
patients with chronic critical limb ischemia. Patients will be randomized into two groups of
equal number; patients in one group will be implanted with mononuclear cells and mesenchymal
stem cells, and the other implanted with mononuclear cells only in the area of affected limb.