This study is being done to see if the investigators can help the immune system to work
A dendritic cell is another type of white blood cell. It has most, if not all, of the
proteins needed to make T cells work to destroy cancer cells. However, dendritic cells do not
normally have the cancer proteins on their surface. The challenge then is to combine the
antigens with dendritic cells to make a vaccine. The investigators think that the body's T
cells might then react against the tumor and help destroy it.
This study will see if altered dendritic cells will make T cells work against tumor cells.
The dendritic cells will be made in a lab and will carry the antigens. These cells then will
be injected under the skin.
In this study, the investigators are trying to help the body make a stronger immune response
against the cancer. The patient will get the same kind of dendritic cell vaccine used in the
earlier study, but with one major difference. The dendritic cells will contain messenger-RNA
(mRNA). Cells use mRNA to make proteins. The mRNA will be put into dendritic cells by a
laboratory method called electroporation. The mRNA is never given to the patient directly.
This mRNA will help the dendritic cell make a tumor antigen like what the cancer expresses.
The dendritic cell can then put this tumor antigen on its surface so that the body could make
a stronger immune response against the tumor.