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Your journey
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3Review
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More info
You can access this
clinical trial
if you have
Nonhematologic Malignancies or Lymphoma
and you are
over 18
years old
1
This is an early phase trial to determine
the dosage and safety of the new treatment.
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The purpose

This is an open-label, multicenter, sequential, 5-arm, phase 1 study of oral IXAZOMIB designed to assess drug-drug interaction with ketoconazole (Arm 1), the relative bioavailability of 2 capsule formulations of IXAZOMIB (Arm 2), food effect (Arm 3), drug-drug interaction with rifampin (Arm 4), and drug-drug interaction with clarithromycin (Arm 5) in participants with advanced nonhematologic malignancies or lymphoma.

Provided treatments

  • Drug: Ixazomib 2.5 mg
  • Drug: Ixazomib 4 mg Capsule A
  • Drug: Ixazomib 4 mg Capsule B
  • Drug: Ketoconazole
  • Drug: Rifampin
  • Drug: Clarithromycin
  • Drug: Ixazomib 4 mg Capsule B

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01454076. The sponsor of the trial is Millennium Pharmaceuticals, Inc. and it is looking for 112 volunteers for the current phase.
Official trial title:
A Phase 1 Study of Oral IXAZOMIB (MLN9708) to Assess Relative Bioavailability, Food Effect, Drug-Drug Interaction With Ketoconazole, Clarithromycin or Rifampin; and Safety and Tolerability in Patients With Advanced Nonhematologic Malignancies or Lymphoma