The current norm in clinical practice for the treatment of choroidal neovascular membranes
(CNVM) secondary to Age-related Macular Degeneration(AMD) involves monthly injections of
Ranibizumab until the disease is stabilized. At this point, most physicians tend to follow
one of two treatment regimens. 'Treat -and-observe' entails regular follow-up of stable
patients, with treatment thereafter only in the presence of disease recurrence.
Alternatively, in a 'treat-and-extend' dosing strategy, intervals between treatments are
extended as long as disease remains stable. Many clinicians, who employ a treat-and-extend
dosing regimen, do not extend their treatment intervals beyond 3 months. However, it is
possible that the subgroup of patients on every three months 'treat-and-extend' dosing may
represent a uniquely, stable population that would perform particularly well on an
observational regimen with regular follow-up. We hypothesize that there will be a low CNVM
recurrence rate in wet AMD patients stable on every three months Ranibizumab dosing
('treat-and-extend'), who begin a treat-and-observe protocol.