Cholesterol cristal embolization (CCE) is an orphan multisystem vascular condition occurring
in elderly with severe atherosclerosis.
In most patients, avoiding the precipitating factors and combination of statin and RAS
inhibitor are recommended.
The lack of randomized controlled trial in CCE precludes significant advances. The
investigators decided to assess whether prednisone started early, at mild dosage and for a
short period prevents death and progression to end-stage renal failure in patients with
severe CCE, as compared to placebo.