There are three purposes to this study. The first purpose is to evaluate the value of a
genetic test in determining risk for autism spectrum disorder. Processing for genetic samples
will be completed at the Cleveland Clinic using research equipment provided by IntegraGen.
The second purpose is to identify genetic changes that may be associated with autism spectrum
disorder or attention deficit/hyperactivity disorder. The third purpose is to examine whether
genetic differences and changes may predict which individuals benefit from medicine used to
treat attention problems or other psychiatric difficulties.
Between 600-800 people are expected to participate in this study - approximately 300
individuals with an autism spectrum disorder, 75 individuals with attention
deficit/hyperactivity disorder or another developmental or psychiatric disorder, 100 healthy
siblings, and 125 unrelated individuals without a developmental or psychiatric disorder.
Study procedures will vary based upon the specific group participants are suspected to fall
into (autism, attention deficit/hyperactivity disorder, psychiatric concerns/developmental
delay, healthy sibling, or unrelated healthy control).
- All individuals will be asked to participate in a cheek swab (gently swabbing the inside
of your cheek) to obtain cells used for genetic testing. Genetic material will be stored
with identifiers such as numbers, letters or codes.
- Parents or caregivers will be asked to complete questionnaires that examine medical and
family history as well as current symptoms and quality of life for the participant.
- Participants may undergo speech and language testing. This involves answering questions,
looking at pictures or identifying items.
- Information recorded in participant medical records will be reviewed and collected for