Many of the beneficial metabolic effects of endurance exercise training are not due to
adaptations to weeks, months, or even years of training, but rather much is due to the
response to the most recent exercise session(s). Therefore, the investigators contend that
lifestyle interventions for obese individuals should be tailored to optimize the metabolic
effects of the most recent exercise session(s). But the "dose" of exercise necessary to evoke
these beneficial responses is not known, and the mechanisms responsible for these
improvements are poorly understood. The findings from these studies will: 1) establish the
minimum "dose" of a single exercise session necessary to improve insulin sensitivity the next
day in obese adults, 2) characterize the underlying metabolic factors responsible for the
improvement in insulin sensitivity, and 3) assess the cumulative metabolic adaptations that
occur over days, weeks, and months of a low-intensity/low-volume lifestyle exercise program.
Findings from these studies will provide valuable information for the development of
lifestyle programs aimed at maximizing the key metabolic health benefits of each exercise
session in obese patients.