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More info
You can access this
clinical trial
if you have
Primary Adrenal Insufficiency
and you are
between 18 and 64
years old
2
This is a second phase trial assessing
efficacy and side effects of the new treatment.
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The purpose

Patients with chronic adrenal insufficiency need to adapt their hydrocortisone replacement dose in conditions of physical or psychological stress to prevent life threatening adrenal crisis. In cases of more severe impairment or unsecure gastrointestinal absorption (e.g. gastroenteritis, severe infectious disease), parenteral administration of the hydrocortisone dose is crucial. The study is conducted to offer patients the possibility to perform hydrocortisone self administration in emergency situations in a way of administration which is easy to perform and accepted by the patient. Therefore, pharmacokinetics and safety of subcutaneous hydrocortisone administration will be studied and compared to intramuscular administration.

Provided treatments

  • Drug: Hydrocortisone intramuscular first
  • Drug: Hydrocortisone subcutaneously first

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01450930. The sponsor of the trial is Bruno Allolio and it is looking for 12 volunteers for the current phase.
Official trial title:
Pharmacokinetics of Hydrocortisone After Subcutaneous Administration Compared With Intramuscular Injection in Chronic Adrenal Insufficiency