A 15-gene lung signature was created to identify predictive and prognostic biomarkers for
Non-Small Cell Lung Cancer (NSCLC) patients. The 15-gene signature was validated using a
microarray platform with fresh frozen tumor tissue to place NSCLC patients into high risk and
low risk cohorts with significantly different survivals.
Using fresh frozen tissue can be challenging, so this study attempts simplify the process by
migrating the 15-gene signature from fresh frozen to two alternative tissue formats: Formalin
Fixed Paraffin Embedded (FFPE) and RNAlater.
The gene expressions of the different tissue formats will be compared to see if the fresh
frozen tissue results are similar to the alternative tissue formats.