This is a multi-centre prospective, non-inferiority trial. Patients will be randomized to two
treatment groups in a 1:1 ratio and will be stratified by age, Karnofsky Performance Status
and extent of the surgical resection.
This study will assess the effect of a one-week radiotherapy regimen in comparison with a
three-week radiotherapy regimen on the survival of elderly and/or frail patients with
glioblastoma multiforme (Frail: ≥>50 years old and with a KPS of 50% or less50%-70%; Elderly
and frail: ≥65 years and with a KPS of 50% - 70%; Elderly: ≥65 years and with a KPS of 80% -