Uremic pruritus is still a common phenomenon in patients with end-stage renal failure. It is
regarded as one of the most bothersome symptoms in patients on chronic dialysis.
The pathogenesis of uremic itch remains unclear. Several theories have been proposed like
dryness of the skin, imbalance in divalent ions, peripheral neuropathy and others.
Many treatment modalities have been tried to reduce uremic pruritus, however , the majority
of them produced only temporary improvement. Therefore , every new therapeutic option for
uremic pruritus is desirable.
This study will undertaken to evaluate the efficacy of a cream which included olive oil and
omega-3 fatty acids.
Olive Omega-3 is an efficient product that soothes itchiness of cracked and very dry skin.
The product is unique and based on patented technology developed by the Technion Research and
Development Foundation in Haifa.
Olive Omega-3 is an ointment composed of all natural ingredients. The main active ingredients
are extra virgin olive oil , fish oil and vitamin C. The oils provides the skin with fatty
acids that are vital for its proper functioning and help in the skin recovery. Sugar cane
extract improves the skin's flexibility by removing dead cells and enhancing water retention
in the upper layer of the skin.
When applied on clean skin , the product is quickly absorbed , producing a sensation of
relief within a short time period. Treatment can be repeated as often as required with no
limitations and its use is not contraindicative of any other medical treatment.
Patients and Methods.
About 20 patients on chronic hemodialysis suffering from uremic pruritus will be include in
All patients will undergo dermatologic examination. All patients will be score by intensity
of itching according to 3-point scale , as follows:
1. - patches of fine , powdery scales
2. - moderate scaling with beginning cracks
3. - intense scaling , moderate cracks The patients all applied Olive Omega-3 ointment for
50% of body and Vaseline ointment for the second one. The treatment will repeated twice
daily for two weeks.
At the end of 2 weeks application global tolerance will evaluate using the following 3-point
1. very good
At the same time global agreement of the patients will evaluate according to the following
1. - very satisfactory
2. - satisfactory 3- poorly satisfactory.
Statistical analysis will be performed by use of Wilcoxon test .