Caloric restriction in obese diabetic patients quickly improves glucose control,
independently from weight loss. However, the early effects of a very-low calorie diet (VLCD)
on insulin sensitivity and insulin secretion in morbidly obese patients with type 2 diabetes
are still unclear.
The objective of this study was to investigate the relative contributions of insulin
sensitivity and/or secretion to the improvement in glucose metabolism, after one week of
caloric restriction, in severely obese diabetic patients.
For this purpose, hyperglycemic clamps were performed in 14 severely obese (BMI> 40 kg/m2)
patients with type 2 diabetes in good glucose control (HbA1c <7.5%), before and after 7 days
on VLCD 400 kcal/day.