This is a prospective cross-over study including 10 stable hemodialysis patients with chronic
kidney disease stage 5. The cross-over study lasts 2 weeks with the study dialysis sessions
During one session, the patient will be dialyzed during 4 hours with high volume post
dilution hemodiafiltration (HDF) with an FX800 hemodialyzer (Fresenius Medical Care) and a
blood flow of 300mL/min, dialysate flow of 500mL/min, and substitution flow of 75mL/min.
During the other midweek session, the patient will be dialyzed during 8 hours with high flux
hemodialysis (HD) with an FX80 hemodialyzer (Fresenius Medical Care) and a blood flow of
200mL/min and a dialysate flow of 500mL/min.
The HDF and HD sessions will be randomized. Blood samples will be drawn pre and post dialysis
from the arterial blood line, and after 30min after dialysis start, a blood sample will be
drawn from the inlet and outlet line.
At the dialysate outlet line, partial dialysate collection is performed at the outlet line.
Blood and dialysate samples will be analyzed for a broad range of retention solutes like
small and water soluble solutes, middle molecules, and protein bound solutes.
These data will be further used to calculate solute removal and evaluate any differences
between the solute removal during high volume post dilution HDF and high flux HD.