Further study details as provided by Duke University:
Purpose: To evaluate the feasibility and safety of collecting and infusing autologous
umbilical cord blood (UCB) in newborn infants with hypoplastic left heart syndrome (HLHS).
Study Rationale and Hypotheses: The major goal of this study is to determine whether infusion
of autologous UCB cells in neonates with hypoplastic left heart syndrome is feasible and
safe. The rationale for the study and for the potential benefit of UCB is based upon the
1. Infants with HLHS have significant neural injury evidenced from both prenatal and early
antenatal brain MRI findings and infusion of UCB cells may lessen neural injury.
Although the exact mechanism is unknown, UCB cell infusion may ameliorate neural injury
via paracrine and anti-inflammatory effects that enhance post injury repair and may
promote endogenous functional compensation of other cortical areas resulting in
significant clinical improvements.
2. UCB cells may also enhance cardiac function, minimize scar formation, and reverse
detrimental remodeling after cardiac injury.