The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics and
pharmacodynamics of TRV120027 in subjects with heart failure and mild to moderate renal
Drug: Normal Saline
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Locations near you
Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Full eligibility criteria for NCT01444872
Ages eligible for Study
18 Years to 74 Years
Genders eligible for Study
Accepts Healthy Volunteers
Written Informed Consent
Mild to moderate renal dysfunction
Age 18- <75
Males and females (non-childbearing potential)
Any significant disease or condition that would interfere with the interpretation of safety or efficacy or efficacy data as determined by the Investigator based on medical history, physical examination or laboratory tests
Any other serious life threatening disease that may impair the interpretation of safety or efficacy data from the study as determined by the Investigator
Allergy or clinically-significant intolerance to ARBs or ACE inhibitors
Clinical signs or symptoms of acute decompensated heart failure
Pregnant or lactating
All locations for NCT01444872
United States (4)
Orlando Clinical Research Center
Orlando, Florida, United States, 32809
DaVita Clinical Research
Minneapolis, Minnesota, United States, 55404
Duke Clinical Research Unit
Durham, North Carolina, United States, 27705
New Orleans Center for Clinical Research
Knoxville, Tennessee, United States, 37920
United States (1)
Kalamazoo, Michigan, United States, 49007
View full eligibility
Tris trial is registered with FDA with number: NCT01444872. The sponsor of the trial is Trevena Inc. and it is looking for 17 volunteers for the current phase.
Official trial title: A Randomized, Single-Blind, Placebo-Controlled, Adaptive, Ascending Dose Study to Evaluate the Effects of TRV120027 on Renal Pharmacodynamics in Patients With Heart Failure and Mild to Moderate Renal Dysfunction
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