The purpose of this study is to evaluate the pro-oxidant toxicity of iron injections in
critically ill patients and in healthy volunteers. The investigators hypothesize that the
inflammatory state of critically ill patients will reduce the oxydative stress induced by
iron injections, compared to the one induced in healthy volunteers. It will be an open
"proof-of-concept" study aimed at evaluating iron toxicity in critically ill patients (n=40)
as compared to healthy volunteers (n=40).
The investigators will compare the oxidative stress (principal judgment criteria=
8-iso-PGF2α) following a 100 mg injection of iron (at T0, T2, T6 and T24 hours post
injection) in both groups and the investigators will compare the effect of repeated
injections in the critically ill patients.