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Your journey
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More info
You can access this
clinical trial
if you have
Cancer
and you are
between 18 and 79
years old
1
This is an early phase trial to determine
the dosage and safety of the new treatment.
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The purpose

Metformin is a drug that is normally used to treat people with diabetes. New research has discovered that metformin may also kill cancer stem cells. These cancer stem cells make up only a small portion of a cancer, but may be responsible for resistance to chemotherapy or for causing recurrence of the cancer. Future studies are envisioned to that test the efficacy of administering metformin with chemotherapy. The purpose of this study is to assess the safety of administering metformin in combination with chemotherapy. Since chemotherapy and cancer itself both cause adverse events by themselves, this study is designed to have a run-in stage as well as a subsequent randomization to metformin or no metformin. The primary endpoint will compare the rate of dose-limiting toxicities between these two arms. After a period of 3 weeks for the primary endpoint comparison, all patients will receive metformin.

Provided treatments

  • Drug: Metformin

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01442870. The sponsor of the trial is Tufts Medical Center and it is looking for 105 volunteers for the current phase.
Official trial title:
Prospective Evaluation of Clinical Safety of Combining Metformin With Anticancer Chemotherapy