The purpose of this study is to evaluate the oral bioavailability of the combination
Glimepiride/ extended release Metformin (GLI/METXR) (4/850mg) in healthy Mexican volunteers.
Methods: A prospective, longitudinal, open label, non randomized study, was performed, 24
volunteers were administrated with a single oral dose of GLI/METXR (4/850 mg). Blood samples
were collected over 30 hours. Plasma concentration of both drugs were measured by using
high-performance liquid chromatography (HPLC). Plasma concentration-time curves were plotted
for each volunteer, and pharmacokinetic parameters (PK) were calculated. Adverse events were
determined using clinical and laboratory test results, throughout the study.