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Your journey
1What's a trial
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More info
You can access this
clinical trial
if you have
Paediatric Thyrotoxicosis
and you are
between 2 and 16
years old
This is a trial in the final phase before the treatment is released on the market.
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The purpose

The investigators aim to establish whether biochemical control during anti-thyroid drug therapy in young people with thyrotoxicosis varies depending upon whether a 'block and replace' or 'dose titration' regimen is used. The investigators will also assess remission rates and the frequency of side-effects in the two treatment groups.

Provided treatments

  • Procedure: Block and Replace
  • Procedure: Dose Titration
  • Drug: carbimazole
  • Drug: propylthiouracil
  • Drug: thyroxine

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01436994. The sponsor of the trial is Newcastle-upon-Tyne Hospitals NHS Trust and it is looking for 81 volunteers for the current phase.
Official trial title:
A Randomised Study of Two Anti-thyroid Drug Treatment Regimens in Young People