Background: Dementias (Alzheimer's disease and related syndromes), in their sporadic form,
have multifactorial origin. Several risk factors (RF) are currently recognized like the
cardiovascular RF, some genes of susceptibility, but the impact  of traumatic life events
(TLE), considered as psychosocial RF (Persson & Skoog, 1996; Charles et al, 2006),  of
anxiety and/or depression,  of the premorbid personality (Clément et al, 2003) with his
coping strategies, and  of the lifestyle (which results from the personality), for the
moment are still underestimated. Dementia disease can be clinically preceded by a mild
cognitive impairment (MCI) (Petersen et al, 1996) which is however potentially reversible.
Purpose: Actually, there is no study concerning the rate of conversion from MCI to dementia
according to the presence or not of TLE. The aim of this study is to assess association
between TLE and conversion rate from MCI to dementia.
Methods: Patients with MCI will be recruited in different memory clinics (Limoges and others)
Primary outcome: Occurrence of dementia according to DSM-IV-TR criteria in MCI patients
according to their cumulated score of TLE measured by EVVIE.
Secondary outcomes: Occurrence of dementia in MCI patients according to various other
psychopathological factors: anxiety, depression, apathy, personality features, alexithymia
and resilience levels and life style.
Study design: Epidemiologic cohort longitudinal and prospective multicenter study.