This trial is terminated!
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Your journey
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More info
You can access this
clinical trial
if you have
and you are
between 18 and 35
years old
The phase for this study is not defined.
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The purpose

Age-related macular degeneration (AMD) and glaucoma are among the leading causes of blindness in the western world. Elevated intraocular pressure (IOP) is a well known major risk factor for glaucoma. In addition, there is growing evidence that vascular factors, including arterial hypertension and hypotension, may play a role in the pathogenesis of AMD and glaucoma. To gain more insight into these mechanisms in humans is the primary goal of the present study. Optical coherence tomography (OCT) delivers three dimensional, volumetric reflectivity information through transparent media in vivo. Moreover, the images show a high choroidal penetration and a resolution comparable to an histologic examination when infrared light sources are used. Because of its non-invasive character, OCT provides an ideal method for diagnosis and monitoring of retinal and choroidal abnormalities. The present study aims to investigate whether choroidal thickness is temporarily altered by changes in IOP or systemic hemodynamic parameters. IOP will be increased by the use of a suction cup technique, mean arterial blood pressure will be altered by intravenously administered Phenylephrine or Sodium-Nitroprusside.

Provided treatments

  • Drug: Phenylephrine
  • Drug: Sodium-Nitroprusside
  • Device: Suction Cup
  • Device: Goldmann applanation tonometer
  • Device: 1060nm Optical coherence tomography

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01333891. The sponsor of the trial is Medical University of Vienna and it is looking for 1 volunteers for the current phase.
Official trial title:
Choroidal Thickness During Changes in Intraocular Pressure and Arterial Blood Pressure