Recently, it has been demonstrated that iron overload is associated with the appearance of
labile plasma iron (LPI).
LPI is redox active and is rapidly taken up by cells, leading to a rise in the labile iron
pool (LIP) and catalyzing generation of reactive oxygen species (ROS), which can lead to
The LPI data are mostly derived from thalassemia iron overload research , however, there are
a few data describing LPI and its correlations with the classical iron overload parameters
(ferritin, TSAT) in acute anemias such as MDS Therefore we are going to assess LPI in iron
overloaded myelodysplastic syndromes (MDS) (low and high risk) and primary myelofibrosis, in
order to assess whether it can be used as alternative to the routinely used parameters; TSAT
and ferritin levels.