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Your journey
1What's a trial
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More info
You can access this
clinical trial
if you have
Prehypertension or Mild Hypertension
and you are
over 18
years old
This is an early phase trial to determine
the dosage and safety of the new treatment.
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The purpose

Prehypertension and mild hypertension affect an estimated 157 million U.S. adults. Cardiovascular disease (CVD) risk and associated mortality is elevated in this population. Treatment options are limited consisting of lifestyle modification, which is often ineffective, or drug therapy, which carries risk of side effects. Highly safe, efficacious, and acceptable treatment options for this population are needed. Hawthorn standardized extract (HSE) is approved for use in Europe to treat heart failure, and preliminary evidence suggests it may have a blood pressure lowering effect. However, prior trials of hawthorn have based dosage recommendations on animal studies. Therefore, the investigators propose a dose-finding study to measure the pharmacodynamic effect of three doses of standardized hawthorn extract and placebo.

Provided treatments

  • : Hawthorn
  • : Placebo capsule

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01331486. The sponsor of the trial is University of North Carolina, Chapel Hill and it is looking for 24 volunteers for the current phase.
Official trial title:
Nitric Oxide Mediated Vasodilatory Response to Hawthorn Standardized Extract