The aim of this study is to develop and optimize methods to isolate, propagate and
differentiate adult human neural stem cells from patients with degenerative neurological
disorders like Parkinson's disease.
Procedure: Harvesting of neural stem cells
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Locations near you
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Full eligibility criteria for NCT01329926
Ages eligible for Study
35 Years to 85 Years
Genders eligible for Study
Accepts Healthy Volunteers
Able to give informed consent prior to study
Male or Female with Diagnostic Criteria of Parkinson's disease or neurodegenerative disorder undergoing a neurosurgical procedure
Age 35 to 85 years old
Parkinson's disease not due to trauma, infection, brain tumor, cerebrovascular disease
Hoehn and Yahr Stage III or IV
Parkinson's disease observed in the absence of:
Orthostatic hypotension (drop greater than 20mmHg in mean pressure)
Good general health or stable medical condition well controlled, without contraindications to anesthesia
Patients with severe dementia and brain atrophy on MRI
Patients with severe hypertension; renal, liver, cardiac or other major organ disease; coagulopathy; cancer; other significant systemic illnesses; hepatitis, HIV
Patients older than 85 or younger than 35
Patients who withhold informed consent
Patients with a history of alcohol or drug abuse
Sexually active women of childbearing potential without adequate form of birth control
Evidence of abnormal coagulation or anticoagulant therapy
Pregnancy or lactation
History of seizure disorders or current use of antiepileptic medication
Severe cognitive impairment
Clinically significant laboratory abnormality
All locations for NCT01329926
United States (1)
Los Angeles Neurosurgical Institute
Los Angeles, California, United States, 90211
View full eligibility
Tris trial is registered with FDA with number: NCT01329926. The sponsor of the trial is NeuroGeneration and it is looking for 20 volunteers for the current phase.
Official trial title: Molecular Analysis of Adult Human-derived Neural Stem Cells
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