Android obesity contributes, via insulin resistance and endothelial dysfunction, to the
development of cardiovascular atherosclerosis. It leads to poor quality of life. It is often
associated with metabolic syndrome which includes, whatever the definitions used (National
Education Cholesterol Program, NECP / Adult Treatment Panel III, ATP III or International
Diabetes Federation, IDF), an increased waist measurement, an arterial high blood pressure
and disorders of the glucide and lipid metabolism. The treatment of the current "epidemic" of
obesity and metabolic syndrome in France (12.4 % of obese and 14 % of subjects with metabolic
syndrome) thus requires new therapeutic approaches.
A well-balanced diet and a daily physical activity are the indispensable requirements for the
treatment of obesity and metabolic syndrome. It is possible to associate it to
pharmacological agents, but the results are often partial and transient. Preliminary data
suggest that leucine or arginine supplementation could facilitate the loss of fat mass.
Moreover, the physical exercise has also demonstrated benefits.
Sessions of physical reconditioning (aerobic work + muscular intensification) associated with
a program of specific nutritional supplementation by a mixture of Leucine and Arginine (in
the daytime) could improve the treatment of obese subjects affected by metabolic syndrome.