In order to explore the effect of repetitive TMS, which has shown to be effective in
intractable depression, we will examine resting-state, default-mode network functional
connectivity in patients with major depression. We will use a double-blind, sham-controlled
design. Our target sample size is 60(30 patients will be treated by active rTMS, the other 30
will be treated by sham rTMS). We will apply 10-day course of 10 Hz rTMS on left dorsolateral
prefrontal cortex of the subjects.