The purpose of this study is twofold:
1. To evaluate the effect of LY2189265 on how the body absorbs a blood pressure lowering
drug (lisinopril) in participants with high blood pressure who are currently taking
2. To evaluate the effect of LY2189265 on heart rate and blood pressure in healthy
volunteers when taken with a Beta-blocker drug (metoprolol).
In Part 1, participants will receive four weekly injections of LY2189265 with continued use
of normal lisinopril therapy.
Part 2 is a cross-over study design. Participants will receive a single injection of
LY2189265 in one period, and seven daily doses of metoprolol and a single injection of
LY2189265 in another period.