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Your journey
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More info
You can access this
clinical trial
if you have
Acute Lymphoblastic Leukemia
and you are
between 1 and 30
years old
1
This is an early phase trial to determine
the dosage and safety of the new treatment.
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The purpose

H. Lee Moffitt Cancer Center and Research Institute will be the Sunshine Project Coordinator, but will not be recruiting locally. The purpose of the trial is to study the clinical and biological effects of metformin in combination with standard systemic chemotherapy in a disease (relapsed ALL) that has a dismal outcome, as well as to do a dose escalation study to find the Maximum Tolerated Dose (MTD) of metformin in conjunction with ALL therapy. There have also been analysis of patients enrolled on trials who were diabetics on metformin and their outcome was better than patients on the same trial that were not on metformin as their antihyperglycemic.

Provided treatments

  • Drug: Metformin
  • Drug: Vincristine
  • Drug: Dexamethasone
  • Drug: PEG-asparaginase
  • Drug: Doxorubicin
  • Drug: Intrathecal chemotherapy

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01324180. The sponsor of the trial is H. Lee Moffitt Cancer Center and Research Institute and it is looking for 14 volunteers for the current phase.
Official trial title:
A Phase I Window, Dose Escalating and Safety Trial of Metformin in Combination With Induction Chemotherapy in Relapsed Refractory Acute Lymphoblastic Leukemia: Metformin With Induction Chemotherapy of Vincristine, Dexamethasone, Doxorubicin, and PEG-asparaginase (VPLD)