Patients with Chronic Kidney Disease (CKD) are upto 3.5 times more likely to die from
diseases of heart and blood vessels (Cardiovascular Disease-CVD). Vitamin D insufficiency is
very common in CKD and associated with CVD. Animal studies have shown an improvement in heart
size and function with Vitamin D therapy, although evidence in humans is lacking. The
proposed study will test if oral Vitamin D treatment, in deficient CKD patients, will improve
heart enlargement and function. With these proposed changes the investigators expect to
reduce CVD and deaths in patients with CKD.